Dementia in Parkinson's disease: usefulness of the pill questionnaire.
Identifieur interne : 000A32 ( Main/Exploration ); précédent : 000A31; suivant : 000A33Dementia in Parkinson's disease: usefulness of the pill questionnaire.
Auteurs : Pablo Martinez-Martin [Espagne]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Dementia, Parkinson Disease.
- diagnosis : Dementia, Parkinson Disease.
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Observation, Psychiatric Status Rating Scales, Questionnaires, Severity of Illness Index.
Abstract
The Level I algorithm for the diagnosis of dementia associated with Parkinson's disease (PD-D) recommended by the Movement Disorder Society task force includes a Pill Questionnaire to determine the impact of cognitive decline on daily activities. The objective of this study was to test the performance of the Pill Questionnaire as a screening tool for the detection of dementia (all-cause) in patients with PD and to test the performance of another functional scale substituting the Pill Questionnaire for the diagnosis of "probable PD-D" (pPD-D). Data were collected from 529 patients who had PD in Hoehn and Yahr stages 1 through 5. The measures used include the Scales for Outcomes in PD-Motor (SCOPA-Motor), scales for psychiatric complications, the Mini Mental State Examination, the Clinical Impression of Severity Index, and the Pill Questionnaire. The SCOPA-Motor functional subscale score was categorized as "impact" or "no impact" of PD on daily activities. According to clinical judgment, 13.3% of patients had dementia. For detecting dementia, the Pill Questionnaire had 89% accuracy, although its positive predictive value was 55%. Performance was worse with the categorized SCOPA-Motor subscale. According to the Movement Disorder Society task force criterion, 85 patients (16.1%) had pPD-D. When the Pill Questionnaire was substituted by the categorized SCOPA-Motor subscale, the modified algorithm showed sensitivity, specificity, and accuracy indexes over 90% but had positive predictive value of 66% for pPD-D diagnosis. Although the Pill Questionnaire demonstrated acceptable basic properties as a screening tool for dementia, its positive predictive value was low. The SCOPA-Motor subscale cannot be proposed as a substitute for the Pill Questionnaire.
DOI: 10.1002/mds.25649
PubMed: 24123241
Affiliations:
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Le document en format XML
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Carlos III Institute of Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24123241</idno><idno type="pmid">24123241</idno><idno type="doi">10.1002/mds.25649</idno><idno type="wicri:Area/PubMed/Corpus">000741</idno><idno type="wicri:Area/PubMed/Curation">000741</idno><idno type="wicri:Area/PubMed/Checkpoint">000A41</idno><idno type="wicri:Area/Ncbi/Merge">003D56</idno><idno type="wicri:Area/Ncbi/Curation">003D56</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D56</idno><idno type="wicri:Area/Main/Merge">000A32</idno><idno type="wicri:Area/Main/Curation">000A32</idno><idno type="wicri:Area/Main/Exploration">000A32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dementia in Parkinson's disease: usefulness of the pill questionnaire.</title><author><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name><affiliation wicri:level="3"><nlm:affiliation>Research Unit, Alzheimer Centre Reina Sofia Foundation, and CIBERNED, CIEN Foundation. Carlos III Institute of Health, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Research Unit, Alzheimer Centre Reina Sofia Foundation, and CIBERNED, CIEN Foundation. Carlos III Institute of Health, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cross-Sectional Studies</term><term>Dementia (complications)</term><term>Dementia (diagnosis)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Observation</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Psychiatric Status Rating Scales</term><term>Questionnaires</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Observation</term><term>Psychiatric Status Rating Scales</term><term>Questionnaires</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Level I algorithm for the diagnosis of dementia associated with Parkinson's disease (PD-D) recommended by the Movement Disorder Society task force includes a Pill Questionnaire to determine the impact of cognitive decline on daily activities. The objective of this study was to test the performance of the Pill Questionnaire as a screening tool for the detection of dementia (all-cause) in patients with PD and to test the performance of another functional scale substituting the Pill Questionnaire for the diagnosis of "probable PD-D" (pPD-D). Data were collected from 529 patients who had PD in Hoehn and Yahr stages 1 through 5. The measures used include the Scales for Outcomes in PD-Motor (SCOPA-Motor), scales for psychiatric complications, the Mini Mental State Examination, the Clinical Impression of Severity Index, and the Pill Questionnaire. The SCOPA-Motor functional subscale score was categorized as "impact" or "no impact" of PD on daily activities. According to clinical judgment, 13.3% of patients had dementia. For detecting dementia, the Pill Questionnaire had 89% accuracy, although its positive predictive value was 55%. Performance was worse with the categorized SCOPA-Motor subscale. According to the Movement Disorder Society task force criterion, 85 patients (16.1%) had pPD-D. When the Pill Questionnaire was substituted by the categorized SCOPA-Motor subscale, the modified algorithm showed sensitivity, specificity, and accuracy indexes over 90% but had positive predictive value of 66% for pPD-D diagnosis. Although the Pill Questionnaire demonstrated acceptable basic properties as a screening tool for dementia, its positive predictive value was low. The SCOPA-Motor subscale cannot be proposed as a substitute for the Pill Questionnaire.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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